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Similarly, in microglia mitochondria, levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) have been shown to be regarded as a marker of DNA/ RNA oxidation due to the lack of protection of mitochondrial DNA (mtDNA) by histone proteins and its own limited repair capacity (41)
This leads to the destruction of parietal cells, achlorhydria, and failure to produce intrinsic factor, resulting in vitamin B12 malabsorption
In the case of B12, deficiency is often treated with injections because this method bypasses absorption barriers
The theoretical 3-8% additional weight loss from adding cagrilintide to tirzepatide doesn't justify the significantly amplified side effects, 2-3x higher cost ($1,200-2,400 monthly), lack of physician support for experimental protocols, and unknown long-term safety profile
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